Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis
نویسندگان
چکیده
A 74-year-old woman with extensive lichen planus mucosae (LPM) developed stenotic esophagitis that was refractory to intravenous glucocorticosteroids. Esophageal dilatations to 14 mm width were repeatedly performed without any lasting effect. After introducing oral apremilast, she experienced complete clinical remission within the first 4 weeks of treatment. Control esophagoscopy confirmed a marked recovery of the esophageal mucosa with no recurrence of the former stenosis. Our observation is in line with the case series of Paul et al. [J Am Acad Dermatol 2013;68: 255-261] who first reported on the benefit of apremilast in patients with extensive LPM. Ideally, the effectiveness of apremilast in LPM should be studied in a randomized controlled trial.
منابع مشابه
[Lichen planus with esophageal involvement].
Lichen planus is an inflammatory disease of unknown etiology which may affect the esophagus. Patients with esophageal lichen planus are usually elderly women. The most frequent symptoms are dysphagia and odynophagia. There is usually concomitant oral involvement in cases of esophageal lichen planus. Endoscopic findings include erosions, exudates and stenosis. Systemic steroids are the most effe...
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Dysphagia is not uncommon in gastroenterology practice. The differential diagnosis is wide and includes both mechanical and motility causes. Esophageal lichen planus is uncommon but now increasingly recognized. It occurs in more than half of cases of lichen planus with muco-cutaneous involvement. Often there is a delay in diagnosis and subsequent treatment. The endoscopic picture of esophageal ...
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Background: Apremilast (Otezla®), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, sarcoidosis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis. Apremilast is indicated for the treatment of active psoriatic arthritis in adults. Apremilast has r...
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BACKGROUND "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. We describe a case, diagnosed by autopsy, of licheno...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2016